Anticholinesterase antagonism of succinylcholine phase II block
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چکیده
منابع مشابه
Succinylcholine neuromuscular block in the myasthenia gravis patient.
The decrease of “functional” endplate receptors in MG can decrease the response to the chemical transmitter acetylcholine, as well as to the depolarizing muscle relaxant succinylcholine. In contrast, the decreased “safety margin” results in a marked sensitivity to nondepolarising relaxants. In normal patients, the wide “safety margin” may explain the slow onset of nondepolarizing block, as well...
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In many industrial and non-industrial applications the quality of a process or product is characterized by a relationship between a response variable and one or more explanatory variables. This relationship is referred to as profile. In the past decade, profile monitoring has been extensively studied under the normal response variable, but it has paid a little attention to the profile with the ...
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The plasma concentrations of pyridostigmine were measured in eight patients during the antagonism of non-depolarizing neuromuscular blockade. After the injection i.v. of pyridostigmine bromide 14.6 mg/70 kg, the concentration of the drug rapidly decreased between 2 and 7 min, and then declined more slowly. After 2 h, significant amounts of pyridostigmine were still present in the plasma of all ...
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Vecuronium is hydrolyzed in the body to 3-deacetyl (ORG 7268), 17-deacetyl (ORG NC58), and 3, 17-bis-deacetyl (ORG 7402) derivatives. Interactions of vecuronium and these metabolites were studied in phrenic nerve-hemidiaphragm preparations of rats. As already reported, ORG 7268 had a potent neuromuscular blocking action, and ORG NC58 and ORG 7402 had a weak neuromuscular blocking action. As exp...
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In 20 adult patients undergoing inguinal herniorrhaphy neuromuscular block was induced with tubocurarine 10 mg. In 10 patients, neostigmine 1--2 mg antagonized the block and restored the twitch response to its baseline value. Physostigmine, up to 4 mg, did not produce significant antagonism of the neuromuscular block.
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ژورنال
عنوان ژورنال: Canadian Anaesthetists’ Society Journal
سال: 1983
ISSN: 0008-2856,1496-8975
DOI: 10.1007/bf03015222